ParaHydrogen Induced Polarization (PHIP)

We have a number of ongoing projects in the field of PHIP. There is literally a lot going on in our lab. Provided below is the list of previously and ongoing PHIP related Federally funded projects in Chekmenev Lab:

1) Screening and Monitoring Response to Treatment Using Subsecond Molecular Imaging and Hyperpolarized Contrast Agents (2012-2019) DOD CDMRP: https://cdmrp.army.mil/search.aspx?LOG_NO=BC112431

2) Low-Cost, High-Throughput 3D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI (2015-2021) DOD CDMRP: https://cdmrp.army.mil/search.aspx?LOG_NO=PR140990

3) International Collaboration in Chemistry: Collaborative Research: Development of Novel Catalysts and Approaches for Parahydrogen-Induced Enhancement of Magnetic Resonance (2014-2018) NSF  Chemistry: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1836308

4) Collaborative Research: Exploiting Spin Networks and Efficient Catalyst/Substrate Separations for NMR "SABRE" Enhancement of Complex Systems (2019-2022) NSF  Chemistry: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1904780

5) Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRI (2020-2022) NIH NHLBI: https://grantome.com/grant/NIH/R21-HL154032-01

6) Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in Cancer (2017-2021) NIH NCI: https://grantome.com/grant/NIH/R21-CA220137-03

7) Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imaging (2014-2017) NIH NIBIB https://grantome.com/grant/NIH/R21-EB018014-02

8) Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imaging (2015-2018) NIH NIBIB https://grantome.com/grant/NIH/R21-EB020323-02

9) Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer (2008-2013) NIH NCI K99/R00 https://grantome.com/grant/NIH/R00-CA134749-04

10) New DOD project has been award in July 2020: details are coming soo. We are thrilled to continue our imaging work on hyperpolarized propane gas in sheep animal model