Signal Amplification By Reversible Exchange (SABRE)

We are working on development of SABRE hyperpolarization technique primarily in the context of developing 15N-hyperpolarized molecular contrast agents using SABRE-SHEATH approach pioneered in Chekmenev Lab in collaboration with Theis, Warren and Goodson labs.

Our current efforts are focused on development of hypoxia sensor metronidazole, theragnotic radio-sensitizer nimorazole and pH sensing 15N-based imidazole compounds for molecular imaging of cancer and other diseases.

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Relevant publications (among many on the this topic):

1) Theis, T.; Truong, M. L.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y., Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization. J. Am. Chem. Soc. 2015, 137 (4), 1404-1407. https://pubs.acs.org/doi/10.1021/ja512242d 

2) Truong, M. L.; Theis, T.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y., 15N Hyperpolarization By Reversible Exchange Using SABRE-SHEATH. J. Phys. Chem. C 2015, 119 (16), 8786–8797. https://pubs.acs.org/doi/10.1021/acs.jpcc.5b01799

3) Barskiy, D. A.; Shchepin, R. V.; Coffey, A. M.; Theis, T.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y., Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. J. Am. Chem. Soc. 2016, 138 (26), 8080-8083.  https://pubs.acs.org/doi/10.1021/jacs.6b04784

4) Shchepin, R. V.; Barskiy, D. A.; Coffey, A. M.; Theis, T.; Shi, F.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y., 15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH. ACS Sensors 2016, 1 (6), 640–644. https://doi.org/10.1021/acssensors.6b00231

5) Shchepin, R. V.; Goodson, B. M.; Theis, T.; Warren, W. S.; Chekmenev, E. Y., Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen. ChemPhysChem 2017, 18 (15), 1961–1965. https://doi.org/10.1002/cphc.201700594

6) Barskiy, D. A.; Shchepin, R. V.; Tanner, C. P. N.; Colell, J. F. P.; Goodson, B. M.; Theis, T.; Warren, W. S.; Chekmenev, E. Y., The Absence of Quadrupolar Nuclei Facilitates Efficient 13C Hyperpolarization via Reversible Exchange with Parahydrogen. ChemPhysChem 2017, 18, 1493–1498. https://doi.org/10.1002/cphc.201700416

7) Shchepin, R. V.; Birchall, J. R.; Chukanov, N. V.; Kovtunov, K. V.; Koptyug, I. V.; Theis, T.; Warren, W. S.; Gelovani, J. G.; Goodson, B. M.; Shokouhi, S.; Rosen, M. S.; Yen, Y.-F.; Pham, W.; Chekmenev, E. Y., Hyperpolarizing Concentrated Metronidazole 15NO2 Group Over Six Chemical Bonds with More Than 15% Polarization and 20 Minute Lifetime. Chem. Eur. J. 2019, 25, 8829-8836. https://doi.org/10.1002/chem.201901192

8) Birchall, J. R.; Kabir, M. S. H.; Salnikov, O. G.; Chukanov, N. V.; Svyatova, A.; Kovtunov, K. V.; Koptyug, I. V.; Gelovani, J. G.; Goodson, B. M.; Pham, W.; Chekmenev, E. Y., Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH. Chem. Comm. 2020, 56 (64), 9098-9101. https://doi.org/10.1039/D0CC03994B