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CHEKMENEV 
LAB

Sphere on Spiral Stairs

Signal Amplification By Reversible Exchange (SABRE)

Sphere on Spiral Stairs

We are working on development of SABRE hyperpolarization technique primarily in the context of developing 15N-hyperpolarized molecular contrast agents using SABRE-SHEATH approach pioneered in Chekmenev Lab in collaboration with Theis, Warren and Goodson labs.

Our current efforts are focused on development of hypoxia sensor metronidazole, theragnotic radio-sensitizer nimorazole and pH sensing 15N-based imidazole compounds for molecular imaging of cancer and other diseases.

Relevant publications (among many on the this topic):

1) Theis, T.; Truong, M. L.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y., Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization. J. Am. Chem. Soc. 2015, 137 (4), 1404-1407. https://pubs.acs.org/doi/10.1021/ja512242d 

2) Truong, M. L.; Theis, T.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y., 15N Hyperpolarization By Reversible Exchange Using SABRE-SHEATH. J. Phys. Chem. C 2015, 119 (16), 8786–8797. https://pubs.acs.org/doi/10.1021/acs.jpcc.5b01799

3) Barskiy, D. A.; Shchepin, R. V.; Coffey, A. M.; Theis, T.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y., Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. J. Am. Chem. Soc. 2016, 138 (26), 8080-8083.  https://pubs.acs.org/doi/10.1021/jacs.6b04784

4) Shchepin, R. V.; Barskiy, D. A.; Coffey, A. M.; Theis, T.; Shi, F.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y., 15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH. ACS Sensors 2016, 1 (6), 640–644. https://doi.org/10.1021/acssensors.6b00231

5) Shchepin, R. V.; Goodson, B. M.; Theis, T.; Warren, W. S.; Chekmenev, E. Y., Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen. ChemPhysChem 2017, 18 (15), 1961–1965. https://doi.org/10.1002/cphc.201700594

6) Barskiy, D. A.; Shchepin, R. V.; Tanner, C. P. N.; Colell, J. F. P.; Goodson, B. M.; Theis, T.; Warren, W. S.; Chekmenev, E. Y., The Absence of Quadrupolar Nuclei Facilitates Efficient 13C Hyperpolarization via Reversible Exchange with Parahydrogen. ChemPhysChem 2017, 18, 1493–1498. https://doi.org/10.1002/cphc.201700416

7) Shchepin, R. V.; Birchall, J. R.; Chukanov, N. V.; Kovtunov, K. V.; Koptyug, I. V.; Theis, T.; Warren, W. S.; Gelovani, J. G.; Goodson, B. M.; Shokouhi, S.; Rosen, M. S.; Yen, Y.-F.; Pham, W.; Chekmenev, E. Y., Hyperpolarizing Concentrated Metronidazole 15NO2 Group Over Six Chemical Bonds with More Than 15% Polarization and 20 Minute Lifetime. Chem. Eur. J. 2019, 25, 8829-8836. https://doi.org/10.1002/chem.201901192

8) Birchall, J. R.; Kabir, M. S. H.; Salnikov, O. G.; Chukanov, N. V.; Svyatova, A.; Kovtunov, K. V.; Koptyug, I. V.; Gelovani, J. G.; Goodson, B. M.; Pham, W.; Chekmenev, E. Y., Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH. Chem. Comm. 2020, 56 (64), 9098-9101. https://doi.org/10.1039/D0CC03994B

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